Friday, October 18, 2013

High Out-of-Pocket Costs Called a Hidden 'Side Effect' of Treatment

High Out-of-Pocket Costs Called a Hidden 'Side Effect' of Treatment

News Picture: High Out-of-Pocket Costs Called a Hidden 'Side Effect' of TreatmentBy Dennis Thompson
HealthDay Reporter

WEDNESDAY, Oct. 16 (HealthDay News) -- Doctors should consider the "toxic" effects of medical debt as much as any other side effect when discussing treatment options with patients, a trio of physicians contends.

By not making potential expense a part of the conversation regarding treatment options, doctors are exposing patients to financial troubles that could compound their health struggles, the Duke physicians wrote in an opinion piece in the Oct. 17 New England Journal of Medicine.

"Since health care providers don't often discuss potential costs before ordering diagnostic tests or making treatment decisions, patients may unknowingly face daunting and potentially avoidable health care bills," the physicians wrote. "Because treatments can be 'financially toxic,' imposing out-of-pocket costs that may impair patients' well-being, we contend that physicians need to disclose the financial consequences of treatment alternatives just as they inform patients about treatments' side effects."

The physicians argue that doctors should consider financial discussions part of their traditional duties, even if they need to receive more training to better understand the expense of treatments to patients.

Nearly two-thirds of personal bankruptcy filings in the United States are due to medical debt, according to the nonprofit National Patient Advocate Foundation. Families run up overwhelming medical bills treating a seriously ill loved one.

Previous studies have shown that more than half of patients want to talk with doctors about the costs of treatment options, but only 19 percent actually have that conversation, said paper co-author Dr. Yousuf Zafar, an assistant professor with the Duke Cancer Institute and the Duke Clinical Research Institute, in Durham, N.C.

"Even though patients have this desire to bring up their growing financial burden, they hadn't had the discussion," Zafar said. "Patients say they want the best care regardless of cost, but in their mind, they link cost to quality. They believe the best care is the most expensive care, and if they talk about cost they might not get the best care."

Zafar began looking into the role of financial information in medical decision-making based on feedback he received from his own patients.

"Patients in my practice as a medical oncologist were coming to me with growing concerns about the cost of their care despite having insurance," he said. "We as physicians don't really know what all of the costs are, but that doesn't mean we shouldn't bring up the topic."

One in five Americans is underinsured, paying at least 10 percent of their annual income on out-of-pocket health care expenses, Zafar said. A serious illness could ruin these people financially.

Reviewing the potential out-of-pocket costs of a procedure can be beneficial to patients, the authors said, by enabling the following:

  • Helping them choose lower-cost treatments when there are viable alternatives.
  • Assisting those who want to make an informed decision about trading potential medical benefit for less financial distress.
  • Allowing them to prepare themselves financially for an expensive procedure.

"Patient expectation plays a role in their level of financial distress," Zafar said. "If patients expect to pay a lot, they are able to cope better. If we prepare patients for the cost, even if we can't reduce the cost, preparation can go a long way."

Further, by considering costs in individual cases of clinical decision-making, doctors could play a crucial part in reducing overall health care costs for society as a whole.

Such conversations would be welcomed by patients, said Kim Bailey, research director for Families USA, a nonprofit health care advocacy group.

"Providers have been really hesitant to talk about cost, and they haven't thought a great deal about cost when talking with their patients about care," Bailey said. "In some ways, it's been seen as the provider's role is to focus solely on medicine, and that discussions of cost is really an insurance role."

It may take some training to help doctors grow comfortable adding a financial dimension to discussion of medical options, paper co-author Zafar said. Medical societies, advocacy groups and medical schools should consider playing a role in such training.

"It's a sensitive topic. It's embarrassing for many patients. And we as physicians don't have the knowledge base to talk about cost," he said. "But we give patients chemotherapy that we know is going to cause a physical toxicity we can't stop. We talk with them about how to best cope and expect it. That's how we should start thinking about the financial toxicity of some of the health care we provide."

For her part, Bailey suggested that physicians daunted by the overwhelming complexity of cost-sharing and different insurance plans might want to start the discussion by asking general questions about patients' financial concerns.

"Maybe the conversation could start there," Bailey said. "'Are you worried about the cost of your treatment? If so, have you looked into what your plan covers?'"

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Copyright © 2013 HealthDay. All rights reserved.

SOURCES: Yousuf Zafar, M.D., assistant professor, Duke Cancer Institute and Duke Clinical Research Institute, Durham, N.C.; Kim Bailey, research director, Families USA; September 2012 issue brief, National Patient Advocate Foundation; Oct. 17, 2013, New England Journal of Medicine


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Shellfish Toxin Spreading to Eastern U.S., Report Says

Shellfish Toxin Spreading to Eastern U.S., Report Says

News Picture: Shellfish Toxin Spreading to Eastern U.S., Report SaysBy Steven Reinberg
HealthDay Reporter

WEDNESDAY, Oct. 16 (HealthDay News) -- An illness-causing bacteria found in shellfish, previously limited to the Pacific Northwest United States, is showing up in East Coast shellfish and in Europe, a new report warns.

The bacteria, Vibrio parahaemolyticus, is the most common cause of seafood-linked stomach illness. Until recently, Pacific shellfish harbored the most virulent strains of Vibrio, but outbreaks on the Atlantic coast of the United States and Spain were reported this year and in 2012.

"This is particularly noteworthy because of the huge distances involved, about 3,000 miles from Pacific to Atlantic seaboards, and 3,000 miles from the Eastern seaboard of the U.S. to Europe," said researcher Craig Baker-Austin, from the Center for Environment, Fisheries and Aquaculture Science in Weymouth, England.

The bacteria is typically found in raw shellfish such as oysters and clams.

Working with colleagues at the U.S. Centers for Disease Control and Prevention, the U.S. Food and Drug Administration and the European Center for Disease Prevention and Control, Baker-Austin said it became apparent that these virulent strains are causing illness in new areas.

In a research letter published in the Oct. 17 issue of the New England Journal of Medicine, the international team of collaborators reports on the spread of the Pacific Northwest Vibrio in 2012.

That year, the CDC identified 28 cases from nine states linked to shellfish from Oyster Bay Harbor in New York. Another 51 people were sickened on a cruise ship in Spain because of cooked seafood that was cooled with ice made from contaminated seawater.

Vibrio usually causes nothing more than stomach distress, including vomiting, abdominal pain and diarrhea. But people with weakened immune systems can suffer severe and life-threatening symptoms.

One doctor said consumers should not eat shellfish indiscriminately. "People should be aware of where their food is coming from," said Dr. Jacqueline Moline, chair of population health at North Shore LIJ Health System in Manhasset, N.Y. "There are significant risks to eating raw or undercooked food."

The implications of Vibrio's long-distance movement are unknown, but concerning, Baker-Austin said.

"In the mid-1990s, a variant of Vibrio emerged in Asia -- termed the pandemic complex -- and quickly moved around the world, causing huge numbers of infections," Baker-Austin said. "Although this has not yet happened with these Pacific Northwest strains, the potential for this to happen should be recognized and assessed properly."

This year in the United States, shellfishery closings in six states -- four in the Northeast -- were attributed to Vibrio.

The researchers aren't sure why or how Vibrio has spread, but they suspect human interference. It's possible that ships' ballast water or long-distance shipping carried the bacteria to new regions, they suggested.

Moline said global warming may play a part in Vibrio's growth.

"Higher than normal seawater temperatures are associated with the increase in the prevalence of this bacterial strain and illnesses associated with it," Moline said.

As oceans continue to warm, more foodborne illnesses will likely appear, she said. "People need to be aware of how environmental changes may be affecting all of us, particularly in terms of food safety," Moline added.

These bacteria can be killed by thoroughly cooking food, she said.

This is critical for immunocompromised persons, particularly those with chronic liver disease, because Vibrio can cause a severe bloodstream illness that is fatal about 50 percent of the time.

Vibrio can also cause serious skin infections when open wounds are exposed to warm seawater.

Baker-Austin said cooperation among international agencies -- the backbone of this current research -- "is required to understand and tackle these types of emerging disease threats."

What's really needed, he added, are "better systems internationally to identify, monitor and report these bacteria and their associated infections in a timely manner."

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Copyright © 2013 HealthDay. All rights reserved.

SOURCES: Craig Baker-Austin, Ph.D., Center for Environment, Fisheries and Aquaculture Science, Weymouth, England; Jacqueline Moline, M.D., chair, population health, North Shore LIJ Health System, Manhasset, N.Y.; Oct. 17, 2013, New England Journal of Medicine


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Immune Protein Found to Block HIV Spread in Some People

Immune Protein Found to Block HIV Spread in Some People

News Picture: Immune Protein Found to Block HIV Spread in Some People

WEDNESDAY, Oct. 16 (HealthDay News) -- One percent of people infected with HIV have a second line of defense deep in their immune system, which serves as a back-up for the body's defenses that get wiped out by the virus, according to a new study.

These people, known as "controllers," are able to maintain long-term control of HIV without a daily regimen of antiviral medication because of a defensive immune protein, known as A3, which blocks the virus from spreading throughout their body.

Scientists from Northwestern University suggested their findings could help shorten the drug treatment required for others who have HIV, the virus that causes AIDS.

"Preserving and even increasing this defense in cells may make more HIV-infected persons into controllers and prevent HIV from rebounding to high and damaging levels when anti-HIV medications are stopped," the study's senior author, Dr. Richard D'Aquila, director of Northwestern's HIV Translational Research Center, said in a university news release.

In conducting the study, published online Oct. 16 in PLoS ONE, the researchers analyzed the cells of controllers in a lab. They found that these rare individuals have a greater supply of the A3 protein in specific white blood cells called resting memory T cells. Any new HIV made from those cells is rendered harmless by A3 and is unable to infect other cells.

Unlike other cells in the immune system that are unable to recognize HIV once it mutates, A3 is part of the so-called intrinsic immune system that isn't fooled by the virus. "The intrinsic immune system recognizes the basic guts of the virus -- the nucleic acids -- that HIV can't change and then damages those nucleic acids," D'Aquila explained.

The researchers suggested that earlier treatment could help others eventually maintain control of their HIV without medication by protecting their reserves of A3.

"Perhaps starting anti-HIV drugs very soon after HIV is caught, rather than the current practice of waiting until later to start, would work like the controllers' first line of defense," D'Aquila said. "If we preserve A3, it could minimize HIV's spread through the body as this protein seems to do in controllers."

The researchers noted there are several cases of early HIV treatment resulting in long-term control of the virus. For example, in January 2013, a baby born to an HIV-positive woman became infected with the virus but was given anti-HIV drug treatment within 36 hours of birth. That baby is now off antiviral medication and apparently cured of HIV, D'Aquila said.

If HIV remains unchecked for several months, however, the researchers suggested reserves of A3 are simply wiped out. They are currently working to develop a drug that would boost the A3 protein.

"Early-as-possible detection -- much easier with our new technology -- and early drug treatment will be the future of HIV therapy," D'Aquila concluded. He added that the new U.S. health law, the Affordable Care Act, now requires insurance companies to pay for routine HIV testing.

-- Mary Elizabeth Dallas

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Copyright © 2013 HealthDay. All rights reserved.

SOURCE: Northwestern University, news release, Oct. 16, 2013


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Cinnamon May Help Ease Common Cause of Infertility, Study Says

Cinnamon May Help Ease Common Cause of Infertility, Study Says

News Picture: Cinnamon May Help Ease Common Cause of Infertility, Study SaysBy Maureen Salamon
HealthDay Reporter

WEDNESDAY, Oct. 16 (HealthDay News) -- Cinnamon has long been used to add flavor to sweet and savory foods. Now, preliminary research suggests the spice may also help jump-start irregular menstrual cycles in women affected by a common infertility disorder.

A small study by researchers from Columbia University Medical Center in New York City found that women with polycystic ovary syndrome who took inexpensive daily cinnamon supplements experienced nearly twice the menstrual cycles over a six-month period as women with the syndrome given an inactive placebo. Two of the women in the treated group reported spontaneous pregnancies during the trial.

"There is a lot of interest in homeopathic or natural remedies for this condition," said study author Dr. Daniel Kort, a postdoctoral fellow in reproductive endocrinology at the medical center. "This may be something we can do using a totally natural substance that can help a large group of patients."

The study was scheduled for presentation Wednesday at a meeting of the International Federation of Fertility Societies and American Society for Reproductive Medicine in Boston.

An estimated 5 percent to 10 percent of women of childbearing age have polycystic ovary syndrome, with up to 5 million Americans affected. Polycystic ovary syndrome, which involves many of the body's systems, is thought to be caused by insensitivity to the hormone insulin. Typical symptoms include menstrual irregularity, infertility, acne, excess hair growth on the face or body, and thinning scalp hair.

Treatment for polycystic ovary syndrome currently includes weight loss, ovulation-inducing drugs such as clomiphene (brand name Clomid) and diabetes medications such as metformin, said Dr. Avner Hershlag, chief of the Center for Human Reproduction at North Shore University Hospital in Manhasset, N.Y.

Kort said that it's not yet clear exactly why cinnamon may work to regulate menstrual cycles in those with polycystic ovary syndrome, but it may improve the body's ability to process glucose and insulin. Prior research among diabetic patients suggested the spice can reduce insulin resistance.

Of the 16 patients who completed Kort's trial, 11 were given daily 1,500-milligram cinnamon supplements and five were given placebo pills. Diet and activity levels were monitored, and patients completed monthly menstrual calendars.

After six months, women receiving cinnamon had significant improvement in menstrual cycle regularity, having an average of nearly four menstrual periods over that time compared to an average of 2.2 periods among the placebo group. Two women reported spontaneous pregnancies after three months of cinnamon treatment, meaning they became pregnant without additional help.

Polycystic ovary syndrome "is one of the most common causes why women don't have regular menstrual cycles," Kort said. "But the clinical consequences later in life are truly great -- from an increased risk of diabetes and glucose intolerance to endometrial cancer. Many women can go their whole lives without regular menstrual cycles, and it doesn't necessarily bother them until they want to have children."

The 1,500-milligram cinnamon dose was chosen for this trial because it was between the 1,000 to 2,000 mg daily that seemed to have metabolic effects on diabetic patients in earlier research, Kort said. But all doses in that range are cheaply obtained, costing pennies per capsule.

"Compared to most medical therapies these days, the cost is very small," he said.

Although the study suggests a link between cinnamon and improvement of polycystic ovary syndrome, it doesn't establish a direct cause-and-effect relationship.

Still, Hershlag called the study "welcome and interesting" and said he sees no reason women with polycystic ovary syndrome shouldn't use more cinnamon in their food or take cinnamon supplements.

"Any work that's something nutritional in nature and seems to affect the abnormal physiology of polycystic ovaries is welcome," Hershlag said. "If they want to spice up their life and take it, that's fine . . . but I think the best thing to do when you have polycystic ovaries is to be under the control of a physician."

Some women with polycystic ovary syndrome from Kort's clinic are already trying cinnamon supplementation at home in the hopes of regulating their own menstrual cycles, he said, although he acknowledged the spice wasn't likely to be a cure-all for the condition.

"It's unlikely to be the sole source of improvement or to change entire (treatment) protocols," he said. "It's not going to regulate every patient who takes it, but a good percentage who take it may experience some benefit, and the side effects are low. It's relatively cheap and well tolerated."

Some day, Kort added, he hopes to organize a larger trial examining the issue.

Data and conclusions presented at scientific conferences are typically considered preliminary until published in a peer-reviewed medical journal.

MedicalNews
Copyright © 2013 HealthDay. All rights reserved.

SOURCES: Daniel Kort, M.D., postdoctoral fellow, reproductive endocrinology, Columbia University Medical Center, New York, N.Y.; Avner Hershlag, M.D., chief, Center for Human Reproduction, North Shore University Hospital, Manhasset, N.Y.; Oct. 16, 2013, presentation, annual meeting, International Federation of Fertility Societies and American Society for Reproductive Medicine, Boston


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Thursday, October 17, 2013

DMV-Based Campaign Helped Boost Organ Donations

DMV-Based Campaign Helped Boost Organ Donations

News Picture: DMV-Based Campaign Helped Boost Organ Donations

WEDNESDAY, Oct. 16 (HealthDay News) -- An organ-donation campaign based in Illinois Department of Motor Vehicle offices boosted the number of people who registered as donors, according to a new study.

Surveys show that more than 90 percent of Americans support organ donations, but less than half register as donors. The University of Illinois researchers wanted to assess the effect of promoting organ donation at DMV offices, where most people make their decision about organ donation.

The study included 40 DMV offices in the state. Brochures, counter mats and posters were placed in 20 of those offices for four months in 2011. The researchers also trained volunteers at those offices to hand out materials and provide information to visitors. A media campaign with radio, roadside and bus ads took place in the areas served by the offices.

The other 20 offices in the study served as a comparison group.

A significant reduction was seen in the downward trend for organ-donation registration at the 20 offices targeted by the campaign, compared to the other offices, according to the findings in the current issue of the journal Clinical Transplantation.

The improvement was not dramatic but was meaningful because most of those who registered had likely been asked before and declined as part of previous license renewals, said Brian Quick, a professor in the department of communication and in the College of Medicine.

"We were not going after the lowest-hanging fruit [with the campaign]," Quick said in a university news release. "We were seeking people who were resistant to registering as organ donors."

Drivers have been asked about organ donation as part of their license renewal since Illinois created a first-person, legally binding consent registry in 2006.

The reasons people refuse to register as organ donors are unclear, but may involve factors such as fear, distrust and just not wanting to do it, Quick said.

"Our research suggests, however, that individuals are much more likely to say yes when they understand that as many as eight lives can be saved, and 25 others improved, by a single donor," he added.

-- Robert Preidt

MedicalNews
Copyright © 2013 HealthDay. All rights reserved.

SOURCE: University of Illinois, news release, October 2013


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Use of Donor Sperm by Lesbians Rises in Canada, Study Finds

Use of Donor Sperm by Lesbians Rises in Canada, Study Finds

News Picture: Use of Donor Sperm by Lesbians Rises in Canada, Study Finds

TUESDAY, Oct. 15 (HealthDay News) -- Use of donor sperm by lesbian couples increased significantly after gay marriage was legalized in the province of Ontario, Canada, a new study finds.

Researchers in Toronto analyzed data from their sperm donor program over the past 17 years and found that the proportion of lesbian couples using the program increased from 15 percent to 20 percent of their patients after gay marriage was legalized in 2003.

The number of units of donor sperm used by lesbian couples increased fourfold, from 133 to 561, according to the findings, which were scheduled for presentation Tuesday at the annual meeting of the International Federation of Fertility Societies and the American Society for Reproduction Medicine, in Boston.

"There is no question that broad social trends have a huge impact on reproduction, and on reproductive medicine," IFFS President Joe Leigh Simpson said in a federation news release. "It is nice to have some actual data which documents how some of these trends impact our profession and, more importantly, our patients."

The study also found that 15 percent of single women and women in heterosexual relationships used donor sperm for in vitro fertilization, compared with 7 percent of lesbian women.

Data and conclusions presented at medical meetings typically are considered preliminary until published in a peer-reviewed medical journal.

-- Robert Preidt

MedicalNews
Copyright © 2013 HealthDay. All rights reserved.

SOURCE: International Federation of Fertility Societies, news release, Oct. 15, 2013


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Children Benefit From Early Dose of Measles Vaccine, Study Finds

Children Benefit From Early Dose of Measles Vaccine, Study Finds

News Picture: Children Benefit From Early Dose of Measles Vaccine, Study Finds

TUESDAY, Oct. 15 (HealthDay News) -- Children should receive their first dose of the measles vaccine when they are between 1 year and 15 months old to best avoid the side effects of the shot, according to a new report.

Researchers from Kaiser Permanente Colorado's Institute for Health Research found that when the first dose of the measles immunization is administered earlier, children have a lower increased risk of fever and seizures. The study is published in the Oct. 14 online edition of JAMA Pediatrics.

"We found that the magnitude of increased risk of fever and seizures following immunization with measles-containing vaccines during the second year of life depends on age," study lead author, Dr. Ali Rowhani-Rahbar, said in a Kaiser Permanente news release.

"While measles-containing vaccines administered at 12 to 15 months of age are associated with a small risk of fever and seizures following immunization, delayed administration at 16 to 23 months of age results in a greater risk of those adverse events," Rowhani-Rahbar added.

The U.S. Centers for Disease Control and Prevention recommends that all children receive their first of the two-dose series of measles vaccine at 12 to 15 months of age. But, the researchers pointed out, most children receive their first dose between 12 and 23 months of age, and only 85 percent of children had received this immunization by the time they are 19 months old.

The researchers used data from the Vaccine Safety Datalink to examine the effect of children's age on their risk for fever and seizures after a measles vaccination. The investigators considered various combinations of vaccines, including: any measles-containing vaccines; the measles, mumps, rubella and varicella vaccine (MMRV); and the measles, mumps and rubella vaccine (MMR) provided with or without a separate varicella vaccine.

After analyzing the records of over 840,000 children aged 12 months to 23 months who received a measles vaccine between 2001 and 2011, the researchers found that after receiving any measles vaccine, all children had an increased risk for fever and seizures seven to 10 days after their immunization. The relative risk of these adverse side effects during this time frame, however, was much lower among those between 12 months and 15 months of age than those between 16 months and 23 months of age.

Rates of fever dropped steadily, however, 12 to 13 days after the first dose of the vaccine for children between 19 months and 23 months of age. Seizures, the study revealed, were most prevalent among children between 16 months and 18 months of age.

The researchers noted that rates of fever and seizures seven to 10 days after the children received their immunization were much higher for those who received the MMRV vaccine than those who received the MMR vaccine with a separate varicella (chickenpox) vaccine.

"Kaiser Permanente's guidelines for measles-containing vaccines are in line with the CDC's recommendations," Dr. Matthew Daley, a pediatrician and senior investigator at Kaiser Permanente Colorado's Institute for Health Research, said in the news release. "This study's findings reinforce for parents that these vaccines are safer when children receive them at 12 to 15 months of age."

Regardless of children's age when they receive their first dose of the measles vaccine, the researchers pointed out the risk for fever and seizures is still small.

The study's senior author and co-director of the Vaccine Study Center, Dr. Nicola Klein, pointed out in the news release that "concerned parents should understand that the risk for febrile seizures after any measles-containing vaccine is low -- less than one febrile seizure per 1,000 injections."

Previous studies have also shown that measles vaccines administered to children between 1 year and 23 months of age are associated with an increased risk of fever and seizures one to two weeks after the immunization when the vaccine virus replication is at its peak.

-- Mary Elizabeth Dallas

MedicalNews
Copyright © 2013 HealthDay. All rights reserved.

SOURCE: Kaiser Permanente, news release, Oct. 14, 2013


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